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美国国立卫生研究院NCI建筑T30细胞处理模块化设施|由DPR Construction提交

贝塞斯达,医学博士。

Region:

ENR MidAtlantic

所有者:国立卫生研究院

建筑师:珀金斯和威尔

总承包人:DPR建设

ENGINEERS:约翰逊·伯纳特(Johnson Bernat Associates)(民事);Genesis AEC(MEP和GMP顾问)

预制模块供应商:Germfree Laboratories Inc.


该国建造的第一个大型预制和多模块化当前良好制造实践(CGMP)制造工厂也有助于国家癌症研究所提供实验疗法。肿瘤浸润淋巴细胞(TILS)识别并杀死癌细胞。DPR高级项目经理Ignacio Diaz说:“我个人研究了直到……因为我很好奇。”知道tils给患者带来了“最后的希望”,使当时的首次PM变得更加容易,“当您有点疲倦或工作很长的日子时醒来。”

美国国立卫生研究院NCI建筑T30电池处理模块化设施

Photo by Halkin Mason Photography, courtesy of DPR

The $28-million design-build project involved 11-ft by 40-ft prefabricated clean room modules inside a 14,200-gross-sq-ft facility supported by a 30-ft-deep auger pile foundation. Weighing between 40,000 and 50,000 lb, the modules include cell manufacturing suites, cell processing suites, clean room lab space and a cold storage room. Working 40 ft from active NIH facilities required the team to monitor vibrations while rigging modules through the open roof. The team reworked the original rigging plan during design and resequenced structural steel erection to be performed before module delivery instead of after, because NIH’s altered workflow required extensive program changes. “We re-engineered part of the exterior steel so it could stand up independently,” Diaz says, “to stand up like flagpoles.”

美国国立卫生研究院NCI建筑T30电池处理模块化设施

该团队建立了美国第一个大型预制和多模块化当前良好的制造实践制造工厂。
Photo by Ulf Wallin Photography, courtesy of DPR

Diaz says “mixed dirt” created by decades of area utility work, along with unreliable as-builts, rendered ground-penetrating radar useless. “We found huge 10-ft-wide tree stumps over 2 ft deep when we’re trying to drill auger piles,” he says. “Not only that, but we were doing all this during the rainiest year in the D.C. area.”
团队互相帮助“学习设计模块化CGMP建筑的细微差别”,珀金斯&Will校长Jeffrey Welter说。一起访问预制设施,导致了“从设计到执行的统一愿景”。