在马萨诸塞州达特茅斯商业园区的疫苗制造设施正在进行现场工作，并计划为Covid-19和其他传染病开发新的疫苗。
新泽西州查塔姆的Tonix Pharmaceuticals计划在达特茅斯（Dartmouth）新贝德福德商业园（New Bedford Business Park）建造45,000平方英尺的临床规模制造设施。该设施预计将在2022年上半年运营。
临床阶段的生物制药公司拒绝透露该项目的成本。
新英格兰地区沃本（Woburn），马萨诸塞州沃本（Woburn）的IPS工程师，该项目记录的建筑师和工程师Dean Poillucci表示，红衣主教集团的工作人员参与了平板切割和拆除，以适应地下公用事业服务，并为新的配件准备新的配件。“巴特勒建造预制的仓库类型结构。”该团队计划在现有的70年代ERA结构的一个角落增加4,000平方英尺的添加。他说，工作人员将修改立面并进行内部结构改进或增加设备。
"The project is a significant renovation; all that remained of the existing building were the roof and walls," says Bill Held, principal at the Cardinal Group of Woburn, Mass. The Cardinal Group’s New England construction division is taking an integrated project delivery approach “to match the technical expertise and experience required to deliver the project with the quickest delivery schedule possible,” IPS said. It noted “the project is unique as Tonix is a virtual company and this project is their first facility of this type.”
减轻紧张的劳动和供应链挑战
Poillucci说，最大的建筑挑战是“超级进取的时间表，紧密的劳动力市场和高强度的生命科学项目”。新利18备用网址他指出，新英格兰承包商的关键供应链资源的可用性有限。
“We started engaging on the construction side way before the design was developed, giving them as much advance notice as possible and letting them know we wanted them to be part of the project; that is absolutely the key piece,” Poillucci says. “For people who come out of the gate cold, and want to start calling contractors, the availability is not there for that type of reaction,” he says
IPS as an integrated engineering, procurement and construction management (EPCM) company, was also “able to stagger the design to meet the long-lead material items and order those way in advance over normal method of delivery,” Poillucci says. This allowed it to “highly mitigate the long lead time issues with equipment and materials.”
GMP疫苗生产
托尼克斯说，该新设施旨在容纳Tonix的高级开发中心（ADC），用于加速研究，开发和分析能力，以及包括Covid-19在内的临床试验质量疫苗的生产。预计它将在2022年上半年进行运营，并充分雇用70名研究人员，科学家，制造业和技术支持人员。
IPS说，生物安全2级ADC实验室将包括一次性生物反应器和纯化套件，配备良好制造实践的设备（GMP）生产用于临床试验的疫苗。它指出，当完全运行时，它将能够在玻璃瓶中生产无菌疫苗并适应“研究，开发和支持分析能力”。
托尼克斯总裁兼首席执行官塞思·莱德曼（Seth Lederman）表示，该项目提供了“竞争优势，尤其是在目前需要更多国内开发和制造能力的Covid-19环境中。”
Lederman supported opening the plant near Boston because of the pool of life sciences talent there, but opted to locate 60 miles south of the city to avoid traffic congestion and real estate costs.
Poillucci说，宾夕法尼亚州贝尔的支柱工程设计了IPS的结构钢设计子培养基设计了一种“满足设施和建筑需求的机械过程要求”的结构，Poillucci说。Due to the facility type, two key challenges involved “a large amount of coordination with the manufacturing spaces below the structure and assuring that the vertical heights of the building available to the project weren’t compromised due to the stacking of the structure in the existing space,” he says.
Steel reinforcement was required to accommodate heavy equipment at roof penetrations and at the openings of area intake and exhaust plenums, Poillucci adds.
